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Finding a Path to a Seizure-Free Future

It takes a multidisciplinary team to find the right treatment for epilepsy — which is why Kathleen Simpson turned to UW Medicine’s Regional Epilepsy Center at Harborview.

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Kathleen and Brooks Simpson outside with their dog.

Kathleen and Brooks Simpson’s experiences with UW Medicine’s Regional Epilepsy Center have led to a deep appreciation of the exceptional care it provides and why it — and the NSI at Harborview — are unique.

When Kathleen Simpson went to bed one night in the Mercer Island home she shares with her husband, Brooks, she didn’t expect to wake up at Harborview Medical Center. And to this day, she has little memory of what happened in between.

Brooks remembers being awakened by her convulsions, and he became terrified when he couldn’t rouse her into consciousness. There was also a gurgling sound to her breathing, which made him think she was going into cardiac arrest — as the CEO and president of a medical distributor of cardiovascular devices, it’s a condition he’s more than familiar with. He called 911 and was preparing to perform CPR when the first responder arrived quickly followed by the paramedics who transported her to Harborview’s emergency room.

Fortunately, it wasn’t a heart attack or a stroke, and after a couple of hours, Kathleen regained consciousness. Her memory was still fuzzy — at first, she didn’t know what day it was — but her CT scans were fine. Doctors determined that her seizure was most likely an isolated event, which, scary as it felt at the time, isn’t that unusual.

Good news, but also a little disconcerting.

“When you go in and you have a broken arm, you get a cast,” says Brooks. “But with something like this, you leave with a very odd experience because they don’t have an answer for you. Will there be another one? When will it happen? You wonder how life will proceed.”

"We have world-class input running the gamut from radiology to neuropsychology to nursing and electrophysiology. This allows our team to come up with the best therapy for our patients through joint decision-making and account for the fact that we are not just treating seizures: we are treating the patient as a whole."

A mysterious condition with a life-changing impact

One in 10 people worldwide will experience a seizure in their lifetime and never have another one. Epilepsy is usually diagnosed when someone has two or more seizures that are unprovoked, meaning they’re not caused by some other factor like low blood sugar or a sudden high fever.

Epilepsy is very common — almost 3 million people in the U.S. live with the condition and about 150,000 are diagnosed each year — but it can have a huge impact on a person’s life. Imagine suddenly losing consciousness while driving, for instance, or taking care of a child.

Dr. Nicholas Poolos

Dr. Nicholas Poolos

Nicholas Poolos, MD, director of the UW Medicine Regional Epilepsy Center (REC) at Harborview, says, “Most of the time, we can’t identify a cause unless it’s something like a head injury, or we suspect that it’s genetic because there’s a family history. And for most people that’s really frustrating. They want to know why.”

What is known is that during a seizure, the brain experiences an electrical storm — like a power surge of neural activity — which can cause involuntary body movements, sensations and behaviors and loss of consciousness. Most patients benefit from medication, but if they continue to have disabling seizures, they might need surgery to remove the part of the brain that’s causing them.

Regardless of whether someone is experiencing their first seizure or has reached the point of requiring surgical intervention, the UW Medicine Regional Epilepsy Center at Harborview Medical Center offers the highest level of care available for seizure disorders thanks, in part, to the close collaboration between the Department of Neurology and Department of Neurological Surgery.

A Center with Synergy

The UW Medicine Regional Epilepsy Center, located at Harborview Medical Center, is a nationally recognized Level 4 epilepsy center that excels in research, patient care and educating the next generation of medical leaders. Its multidisciplinary approach brings together teams of specialists in adult and pediatric neurology, neurosurgery, neuroradiology, neuropathology and neuropsychology, as well as nurses, social workers, vocational rehabilitation specialists and electrodiagnostic technicians, to offer exceptional, well-rounded care.

“Our goal is to find the treatment for a patient that will offer them the best chance to be seizure-free,” says Poolos. “And it takes a team of people to figure out what the best approach is for them. I think one of the things that makes us unique is the amount of talent we can bring to bear.”

Dr. Andrew Ko

Dr. Andrew Ko

Dr. Andrew Ko, a neurosurgeon with the Center, agrees. “The treatment of epilepsy requires more expertise than one or two people can provide. The fantastic thing about the REC is the depth and breadth of knowledge and experience we have across the entire team.”

He adds that this full-spectrum care includes interpretation of imaging, careful examination of how a person’s epilepsy is affecting the rest of the brain and its function, and long-term monitoring of the electrical activity of the brain.

“We have world-class input running the gamut from radiology to neuropsychology to nursing and electrophysiology,” he says. “This allows our team to come up with the best therapy for our patients through joint decision-making and account for the fact that we are not just treating seizures: we are treating the patient as a whole.”

Finding the way to being seizure-free

Kathleen didn’t have another seizure and all her follow-up tests continued to be fine, so she and Brooks put the frightening episode behind them and resumed their busy lives.

Their connections to the University of Washington, and the medical field, run deep. Both are UW alumni (Brooks’s father was at one time a regent), and Kathleen also holds a master’s in clinical exercise physiology with a specialty in cardiac and pulmonary pathophysiology. Until her retirement, she worked in sales and marketing for medical device companies. In addition to his current role as CEO, Brooks is the board chair for the Washington Research Foundation, a major supporter of UW Medicine, and sits on the UW Foundation’s board of directors.

But five years later, Kathleen had another seizure. Three more followed in three consecutive months. That’s when she was diagnosed with epilepsy at another health system while they were out of town and was placed on Keppra, a medication to treat seizures.

For Kathleen, the drug wasn’t a good fit. “I’m pretty sensitive to medications — I felt so out of it and really couldn’t function. I would sit down and fall asleep.”

A friend strongly recommended Dr. Poolos, who was able to look at other conditions Kathleen has and find an alternative medication that would work. It was a struggle at first, and she had one more seizure after missing a few doses, but she has been seizure-free since.

The experience led both Kathleen and Brooks to a deep appreciation of the exceptional care the Center provides and why it — and the Neurosciences Institute at Harborview (NSI) — are unique.

“It’s exciting to have a neurologist who is also involved in doing really promising research,” says Kathleen. “We’re finally at a point where we might be able now to answer some of these questions, like what is the cause of this seizure, which can lead to better treatments or even prevent these kinds of diseases.”

Brooks adds, “I’ve been in the medical field for over 40 years — I travel across the nation, and I’ve been to about 80 different countries. What people don’t realize is that when you combine an academic medical center, a Level 1 trauma center, scientific research and infrastructure like Airlift Northwest to get patients the emergency care they need, well, that’s what makes a world-class healthcare system. And we have that right here in our region.”

"Research has to meet a threshold for federal investment. Which is why philanthropy is so important to kickstart the basic science that’s the foundation for these breakthroughs. For the cutting-edge, you need the philanthropy of local folks and organizations."

The meaningful impact donors can have on health

As UW Medicine donors themselves, the Simpsons also recognize that the need for neurological care in our community is growing, and donor support is critical to help increase the number of providers, programs and services.

World-Class Neurological Care for Our Community

Learn more about the world-class, multidisciplinary neurological care provided by the Neurosciences Institute and Harborview Medical Center that’s providing hope to patients and advancing scientific discoveries.

Kathleen says, “I think about all the people we know with different neurological ailments. We desperately need to attract more neurologists and specialists by raising money to support the NSI and Harborview.”

Donor support is also needed to advance the science that will improve health. About 25-30 percent of people with epilepsy will continue to have seizures even with the best treatments currently available.

“Research has to meet a threshold for federal investment,” says Brooks. “Which is why philanthropy is so important to kickstart the basic science that’s the foundation for these breakthroughs. For the cutting-edge, you need the philanthropy of local folks and organizations.”

Poolos notes, “When our faculty have a bright idea that they want to test out, or they want to get a clinical trial off the ground, that’s where philanthropy comes in. It enables things at that ground level to take root and blossom.”

Kathleen is confident that with support from donors, the expert team at the Center can accelerate the speed at which we can find treatments and cures for neurological conditions.

“Our children probably won’t have to deal with these mysteries because we’ll know how to prevent and treat these diseases better,” says Kathleen. “But gosh, it’d be nice to get it moving a little faster.”

Written by Nicole Beattie

Help People with Neurological Conditions

Support epilepsy research, clinical care and education by making a gift to the Epilepsy Center Fund so that more people like Kathleen can live seizure-free. You can also support patients with other neurological conditions by giving to the Harborview Mission of Caring Fund, which ensures that Harborview can provide world-class care to all, or the Neurosciences Institute Fund to expand access to expert neurological care.